Diazoethane → HCID 53995746, compound

Participants

Reaction Steps

To a solution of diazoethane (2.5 mol equivalent) in ether (150 ml), a solution of 3-(2-pyridyloxy)benzoyl chloride in anhydrous ether (90 ml) is added dropwise at -20° C for 40 minutes. The resultant mixture is stirred at -20° C for 20 minutes. The diazoethane is evaporated at -20° C under reduced pressure, and the ether is evaporated at -10° C to 0° C under reduced pressure. The residue is chromatographed on a column of silica gel, which is eluted with 20 % ether/benzene and 30 % ether/benzene to give 3-(2-pyridyloxy)-1-(2-diazopropionyl)benzene (2.87 g) as an oily substance. IR (CCl4): 2060, 1630 cm-1.

Provenance & Evidence