Hydrazine → HCID 12690630, compound

HRID 1730974Notes

Reaction equation

HRID 1730974 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1([OH:21])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[CH:10]=[CH:9][C:8]2[CH:17]=[CH:18][CH:19]=[CH:20][C:7]1=2)C.[NH2:23][NH2:24]>>[OH:21][C:6]1([CH2:5][C:4]([NH:23][NH2:24])=[O:3])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[CH:10]=[CH:9][C:8]2[CH:17]=[CH:18][CH:19]=[CH:20][C:7]1=2

Participants

3

Reactant 2

HCID 9321HydrazineHCID 12690627HCID 12690627, compound

Product 1

HCID 12690630HCID 12690630, compound

Procedure

A mixture of 4.0 g. of 5-hydroxy-dibenzo[a,d]cyclohepten-5-acetic acid ethyl ester and 8 ml. of anhydrous hydrazine is warmed with stirring at temperature of 80°-85° C. for 2 hours, and then allowed to stand at room temperature for 19 hours. The resulting mixture is evaporated to dryness in high vacuum at 100° C., the residue dissolved in hot ethanol, treated with charcoal and crystallized to obtain 5-hydroxy-dibenzo[a,d]cyclohepten-5-acetic acid hydrazide, m.p. 192°-194° C.

Workup

  1. additionA mixture of 4.0 g
  2. waitto stand at room temperature for 19 hours
  3. customThe resulting mixture is evaporated to dryness in high vacuum at 100° C.
  4. dissolutionthe residue dissolved in hot ethanol
  5. additiontreated with charcoal
  6. customcrystallized

Sources & evidence

ORD record
ord-08f93a33e9df493985cc944e1bc6cad2
Source dataset
uspto-grants-1976_11
Patent number
US03994918

Reaction notes

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