Ethylenediamine → HCID 10702373, compound

HRID 1730979Notes

Reaction equation

HRID 1730979 reaction equation
CO[C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=O)C1C=CC(OC)=CC=1.[CH2:21]([NH2:24])[CH2:22][NH2:23]>>[NH:23]1[CH:10]2[C:5]3[C:4]([C:3](=[O:20])[N:24]2[CH2:21][CH2:22]1)=[CH:9][CH:8]=[CH:7][CH:6]=3

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 226207methyl 2-(4-methoxybenzoyl)benzoate

Product 1

HCID 10702373HCID 10702373, compound

Procedure

Condense methyl-o-(p-methoxybenzoyl)benzoate (7 g.) and ethylenediamine (8 ml.) by procedure of Example 1 to obtain 9b-p-methoxyphenyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one, m.p. 159° C. (elemental analysis confirms the empirical formula C17H16N2O2), reduce with lithium aluminum hydride, and treat with hydrogen chloride as described in Example 1 to obtain 1,2,3,4,5,6-hexahydro-1-(p-methoxyphenyl)-2,5-benzodiazocine dihydrochloride, m.p. 260° C.

Sources & evidence

ORD record
ord-774c4d604b694564baff65098b8071a3
Source dataset
uspto-grants-1976_11
Patent number
US03994920

Reaction notes

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