HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylaminoethyl chloride → 1-{4-[2-(Diethylamino)ethoxy]phenyl}-2-phenyl-4(1H)-quinolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylaminoethyl chloride | HCID 13364 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 1-(4-hydroxyphenyl)-2-phenyl-4(1H)-quinolone | HCID 21398476 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 1-{4-[2-(Diethylamino)ethoxy]phenyl}-2-phenyl-4(1H)-quinolone | HCID 21398486 | — |
Reaction Steps
By following a procedure similar to that described in Example 1 and using 49.5 g. 1-(4-hydroxyphenyl)-2-phenyl-4(1H)-quinolone, 10.5 g. sodium methoxide, 500 ml. chlorobenzene, 45 ml. dry methyl alcohol, and 26 g. N-(2-chloroethyl)diethylamine in 80 ml. chlorobenzene there was obtained on evaporation to dryness of the chloroform extract and recrystallization from isopropyl alcohol 32 g. 1-{4-[2-(diethylamino)ethoxy]phenyl}-2-phenyl-4(1H)-quinolone; m.p. 115°-117°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994902 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-0d95991ac8d84780a29d7fe46b574f8d |
| Source note | uspto-grants-1976_11 |