HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium → HCID 131710545, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | HCID 131710546 | HCID 131710546 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131710545 | HCID 131710545 | — |
Reaction Steps
200 mg. of natural 17β-acetoxy-18-methyl-17α-ethinyl-15α,16α-methylene-4-estren-3-one is mixed in 20 ml. of absolute tetrahydrofuran with 670 mg. of lithium tri-tert.-butoxyalanate and agitated for 1 hour at room temperature. The mixture is then worked up analogously to Example 17. After chromatography on silica gel, 160 mg. of natural 3β-hydroxy-17β-acetoxy-18-methyl-17α-ethinyl-15α,16α-methylene-4-estrene is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994937 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-c179a6f5bed54a3fad61df403d7543bd |
| Source note | uspto-grants-1976_11 |