反应详情

To 2.9 g. (0.01 mol.) of N-t-butoxycarbonyl-2-acetoxyglycine n-butyl ester in 10 ml. of dioxane was added a solution of sodium phenolate prepared from 0.94 g. of phenol and 0.54 g. of sodium methoxide in 15 ml. of dioxane. After refluxing for 2 hours, the solvent was evaporated in vacuo and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with cold 10% aqueous sodium hydroxide, dried (MgSO4) and concentrated to yield the title compound as an oil.

1. customprepared from 0.94 g
2. temperatureAfter refluxing for 2 hours
3. customthe solvent was evaporated in vacuo
4. dissolutionthe residue was dissolved in ethyl acetate
5. washThe ethyl acetate solution was washed with cold 10% aqueous sodium hydroxide
6. dry with materialdried (MgSO4)
7. concentrationconcentrated