Phosphorus pentachloride → HCID 178479509, compound

HRID 1731057Notes

Reaction equation

HRID 1731057 reaction equation
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[C:7]([NH:10][C:11](=[O:17])[NH:12][CH2:13][C:14](O)=[O:15])(=[NH:9])[NH2:8]>C(Cl)Cl>[ClH:2].[C:7]([NH:10][C:11](=[O:17])[NH:12][CH2:13][C:14]([Cl:2])=[O:15])(=[NH:9])[NH2:8]

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 178513106HCID 178513106, compound

Product 1

HCID 178479509HCID 178479509, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
10 °C

Procedure

To 1 gal. of methylene chloride under a nitrogen atmosphere is added 229.06 g. (1.1 moles) of phosphorous pentachloride, and the resulting solution cooled to 10° C. While maintaining the temperature at 10° C., 160.13 g. (1 mole) of guanylureidoacetic acid is added portionwise, and the resulting reaction mixture allowed to stir at room temperature overnight. The product is filtered, washed with dry methylene chloride and used immediately in subsequent reactions without further purification.

Workup

  1. customthe resulting reaction mixture
  2. filtrationThe product is filtered
  3. washwashed with dry methylene chloride
  4. customused immediately in subsequent reactions without further purification

Sources & evidence

ORD record
ord-82d98ad23e80471c82edeb8bfcf687d7
Source dataset
uspto-grants-1976_11
Patent number
US03994965

Reaction notes

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