HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 8-chloro-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Triazolam | HCID 5556 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 8-chloro-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine | HCID 21494835 | — |
Reaction Steps
In the manner given in Example 1, 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in xylene is heated in an oil bath at 122°-124° C. with repeated addition of portions of paraformaldehyde to give 8-chloro-1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994941 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-e5a5d04ef7024a52b399dc8ce8a50c82 |
| Source note | uspto-grants-1976_11 |