HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 8-chloro-1-(2-hydroxyethyl)-6-(2-pyridyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyclazolam | HCID 20368150 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 8-chloro-1-(2-hydroxyethyl)-6-(2-pyridyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 21494814 | — |
Reaction Steps
In the manner given in Example 1, 8-chloro-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in xylene is heated in an oil bath with repeated additions of portions of paraformaldehyde to give 8-chloro-1-(2-hydroxyethyl)-6-(2-pyridyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994941 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-54044e0c58ec4a439e4d5fa1909f55c1 |
| Source note | uspto-grants-1976_11 |