HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 86734227, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 21494834 | HCID 21494834 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86734227 | HCID 86734227 | — |
Reaction Steps
In the manner given in Example 22, 1-(2-aminoethyl)-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in acetonitrile is treated with 37% aqueous formaldehyde and acetic acid and thereafter with sodium cyanoborohydride and the resulting boron complex is warmed with aqueous ethylenediamine to give 1-[2-[(dimethylamino)-ethyl]-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994941 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-511a5d3beabb45279843f80f1d5b44ac |
| Source note | uspto-grants-1976_11 |