HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 8-chloro-1-(2-hydroxyethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Alprazolam | HCID 2118 | — |
| Product | 8-chloro-1-(2-hydroxyethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12562508 | — |
Reaction Steps
heating 8-chloro-6-phenyl-1-methyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in an inert organic solvent with paraformaldehyde to 100°-140° C. to give 8-chloro-1-(2-hydroxyethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994941 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-9a878b20f7c04d5298059dc8e3243778 |
| Source note | uspto-grants-1976_11 |