HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 1-[2-(dimethylamino)ethyl]-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2',5-dichloro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone | HCID 21494795 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[2-(dimethylamino)ethyl]-8-chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12612417 | — |
Reaction Steps
In the manner given in Example 1C, 2',5-dichloro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine to give 1-[2-(dimethylamino)ethyl]-8 -chloro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine of melting point 150°-153° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994940 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-0aadd180a56b496fa2e99e8a5dd318a5 |
| Source note | uspto-grants-1976_11 |