Hydrazine → HCID 21494724, compound

HRID 1731115Notes

Reaction equation

HRID 1731115 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21][N:22]2C(=O)C3=CC=CC=C3C2=O)=[N:19][N:18]=[C:17]1[CH2:33][CH2:34][N:35]([CH3:37])[CH3:36].NN>C(O)C>[CH3:36][N:35]([CH3:37])[CH2:34][CH2:33][C:17]1[N:16]2[C:10]3[CH:11]=[CH:12][C:13]([F:15])=[CH:14][C:9]=3[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])=[N:22][CH2:21][C:20]2=[N:19][N:18]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 21494727HCID 21494727, compound

Product 1

HCID 21494724HCID 21494724, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1C, 2'-chloro-5-fluoro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine to give 1-[2-(dimethylamino)ethyl]-8-fluoro-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-b60360b026d943d598cdd34be889b4c1
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

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