5-Amino-4-(pyrimidin-4-yl)-1H-pyrazole-1-carboximidamide → HCID 21495091, compound

HRID 1731119Notes

Reaction equation

HRID 1731119 reaction equation
[C:1](N1C(N)=C(C2C=CN=CC=2)C=N1)(=N)N.[C:16]([N:19]1[C:23]([NH2:24])=[C:22]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][N:26]=2)[CH:21]=[N:20]1)(=[NH:18])[NH2:17]>>[NH2:18][C:16]1[N:19]2[N:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][N:28]=[CH:27][N:26]=3)=[C:23]2[N:24]=[CH:1][N:17]=1

Participants

3

Reactant 2

HCID 214950875-Amino-4-(pyrimidin-4-yl)-1H-pyrazole-1-carboximidamideHCID 214950895-Amino-4-(pyridin-4-yl)-1H-pyrazole-1-carboximidamide

Product 1

HCID 21495091HCID 21495091, compoundYield 80%

Procedure

By replacing the 1-amidino-4-(4-pyridyl)-5-aminopyrazole in Example 1C with an equivalent quantity of 1-amidino-4-(4-pyrimidinyl)-5-aminopyrazole there is obtained an 80% yield of 4-amino-8-(4-pyrimidinyl)-pyrazolo-[1,5-a][1,3,5]triazine which separates from boiling dimethylformamide in crystals melting at about 340° C. (dec.).

Sources & evidence

ORD record
ord-bdf7f952e70549ee999b21c16977a1f8
Source dataset
uspto-grants-1976_11
Patent number
US03995039

Reaction notes

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