5-Amino-4-(pyrazin-2-yl)-1H-pyrazole-1-carboximidamide → HCID 21495093, compound

HRID 1731120Notes

Reaction equation

HRID 1731120 reaction equation
[C:1](N1C(N)=C(C2C=CN=CC=2)C=N1)(=N)N.[C:16]([N:19]1[C:23]([NH2:24])=[C:22]([C:25]2[CH:30]=[N:29][CH:28]=[CH:27][N:26]=2)[CH:21]=[N:20]1)(=[NH:18])[NH2:17]>>[NH2:18][C:16]1[N:19]2[N:20]=[CH:21][C:22]([C:25]3[CH:30]=[N:29][CH:28]=[CH:27][N:26]=3)=[C:23]2[N:24]=[CH:1][N:17]=1

Participants

3

Reactant 2

HCID 214950885-Amino-4-(pyrazin-2-yl)-1H-pyrazole-1-carboximidamideHCID 214950895-Amino-4-(pyridin-4-yl)-1H-pyrazole-1-carboximidamide

Product 1

HCID 21495093HCID 21495093, compoundYield 75%

Procedure

By replacing the 1-amidino-4-(4-pyridyl)-5-amino-pyrazole employed in Example 1C with an equivalent quantity of 1-amidino-4-(2-pyrazinyl)-5-aminopyrazole and following substantially the same procedure described in Example 1C there is obtained a 75% yield of 4-amino-8-(2-pyrazinyl)-pyrazolo[1,5-a][1,3,5]triazine. The product separates from boiling dimethylformamide in crystals melting above 360° C.

Sources & evidence

ORD record
ord-12e877e02a744fe1af9cb2b892887e10
Source dataset
uspto-grants-1976_11
Patent number
US03995039

Reaction notes

Loading…