HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-Bromo-4-trifluoromethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | Bromine | HCID 24408 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 2-Bromo-4-trifluoromethylaniline | HCID 93899 | — |
Reaction Steps
To 161.0 g of p-aminobenzotrifluoride and 10.0 g of iron filings is added, dropwise, with agitation at 35°-40°, 160.0 g of bromine, using a slow stream of nitrogen to sweep out the evolved hydrogen bromide. Subsequently, the mixture is agitated for an additional two hours and then distilled in vacuo to give 3-bromo-4-aminobenzotrifluoride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03995042 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-3ff8066a6ba24cd98da3a38b29b92197 |
| Source note | uspto-grants-1976_11 |