Water → HCID 86734225, compound

Participants

Reaction Steps

1-Methyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-methanol (9.0 g), described in Example 462, is dissolved in dry pyridine (20 ml.). p-Toluenesulfonyl chloride (7.4 g) is added portionwise to the vigorously stirred and cooled solution. The mixture is stirred further at 0° C for 1 hr., ice and water is then added and the aqueous mixture is extracted with ether. The combined ether extracts are washed with 10% ice-cold hydrochloric acid, water, 5% sodium bicarbonate water and dried (Na2SO4). Concentration of the extracts affords 1-methyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-methyl tosylate.

Provenance & Evidence