Triethyloxonium tetrafluoroborate → HCID 21495341, compound

Participants

Reaction Steps

A solution of triethyloxonium fluoroborate (3.5 g) and the amide of formula X, N,1-dimethyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-propionamide (5.5 g), described in Example 108, in 100 ml of methylene chloride is evaporated at reduced pressure and the residue dissolved in 50 ml of absolute ethanol. Sodium borohydride (1.35 g) is added in portions to the stirred solution at 0° C. When the addition is complete, stirring is continued for 18 hr. at 25° C. The solution is poured into 250 ml of water and extracted with 3 × 30 ml portions of ether. The combined extracts are washed with water, dried (MgSO4) and evaporated yielding the title compound, identical to the product of Example 285.

Provenance & Evidence