反应详情

To a solution of indene-3-ethanol (15 g) in 150 ml of benzene, iodoacetone (12 g) is added. The mixture is heated at reflux with 5 ml of boron trifluoride-etherate and hydrated alkali-aluminum silicate (Molecular Sieves No. 4). After a total of 2 hours the reaction is cooled, filtered and washed with 5% sodium bicarbonate, water and dried over sodium sulfate. Evaporation under reduced pressure affords an oil. This oil is purified by chromatography on silica gel. Elution with benzene and concentration of the eluate gives the title compound, identical to the compound of the same name described in Example 463.

1. temperatureThe mixture is heated
2. temperatureAfter a total of 2 hours the reaction is cooled
3. filtrationfiltered
4. washwashed with 5% sodium bicarbonate, water
5. dry with materialdried over sodium sulfate
6. customEvaporation under reduced pressure
7. customaffords an oil
8. customThis oil is purified by chromatography on silica gel
9. washElution with benzene and concentration of the eluate