反应详情

A mixture of 32 g of 3-methyl-benzophenone (process of Ador et al, Berichte, Vol. 12, p. 2299), 96 ml of carbon tetrachloride, 26 g of N-bromosuccinimide and 100mg of benzoyl peroxide was refluxed for one hour and after the addition of another 100mg of benzoyl peroxide, the mixture was refluxed for 1 hour. Another 100 mg of benzoyl peroxide were added and reflux was maintained for 11/2 hours. Another 100 mg of benzoyl peroxide were added and reflux was maintained with stirring for 11/2 hours. The mixture was cooled, filtered and the filtrate was distilled to dryness under reduced pressure to obtain 46 g of 3-bromomethyl-benzophenone which was used as is for the next step.

1. temperaturewas refluxed for one hour
2. temperaturethe mixture was refluxed for 1 hour
3. temperaturereflux
4. temperaturewas maintained for 11/2 hours
5. temperaturereflux
6. temperaturewas maintained
7. temperatureThe mixture was cooled
8. filtrationfiltered
9. distillationthe filtrate was distilled to dryness under reduced pressure