Thionyl Chloride → HCID 21495641, compound

HRID 1731163Notes

Reaction equation

HRID 1731163 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:8]2[C:9]([CH3:19])=[C:10]([CH2:14][CH2:15][C:16](O)=[O:17])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:8]2[C:9]([CH3:19])=[C:10]([CH2:14][CH2:15][C:16]([Cl:24])=[O:17])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21495630HCID 21495630, compound

Product 1

HCID 21495641HCID 21495641, compound

Procedure

830 mg of 3-(3'-p-chlorobenzoyl-2'-methyl-phenyl)propionic acid and 4.2 ml of thionyl chloride were refluxed for 3 hours and then excess thionyl chloride was distilled off and the last traces were removed by entrainment with benzene to obtain 876 mg of 3-(3'-p-chlorobenzoyl-2'-methyl-phenyl)propionyl chloride which was used as is for the next step.

Workup

  1. distillationexcess thionyl chloride was distilled off
  2. customthe last traces were removed by entrainment with benzene

Sources & evidence

ORD record
ord-669edae59c83423faedce059dea34bcb
Source dataset
uspto-grants-1976_11
Patent number
US03995056

Reaction notes

Loading…