Oxalyl chloride → HCID 21495612, compound

Participants

Reaction Steps

Using the procedure of Step A of Example II, 22.98 g of 3-(m-benzoyl-phenyl)-propionic acid and 115 ml of oxalyl chloride were reacted to obtain 24.59 g of 3-(m-benzoyl phenyl)-propionyl chloride. A solution of the said acid chloride in 50 ml of anhydrous ether was added with stirring at 25° C in 45 minutes to 1,460 ml an ether solution of 10.5 g/liter of diazomethane and the mixture was stirred at 25° C for 16 hours and then evaporated to dryness under reduced pressure to obtain 29 g of raw product which was purified by chromatography over silica with a 95-5 methylene chloride-ethyl acetate eluant which was evaporated to dryness to obtain 19 g of 3-(4'-diazo-3'-oxo-pentyl)-benzophenone. STEP B: 2,3-isopropylidenedioxypropyl 4-(m-benzoyl-phenyl)-2-methyl-butyrate

Provenance & Evidence