Thionyl Chloride → HCID 21495655, compound

HRID 1731193Notes

Reaction equation

HRID 1731193 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[C:9]([O:19][CH3:20])=[C:10]([CH2:14][CH2:15][C:16](O)=[O:17])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.S(Cl)([Cl:25])=O>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([C:8]2[C:9]([O:19][CH3:20])=[C:10]([CH2:14][CH2:15][C:16]([Cl:25])=[O:17])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21495665HCID 21495665, compound

Product 1

HCID 21495655HCID 21495655, compound

Procedure

A solution of 5.1 g of 3-(3'-p-chlorobenzoyl-2'-methoxy-phenyl)-propionic acid in 25 ml of thionyl chloride was refluxed for 21/2 hours and the excess thionyl chloride was distilled off. The residue was taken up in benzene and was evaporated to dryness to obtain 5.6 g of 3-(3'-p-chlorobenzoyl-2'-methoxy-phenyl)-propionyl chloride which was used as is for the next step.

Workup

  1. distillationthe excess thionyl chloride was distilled off
  2. customwas evaporated to dryness

Sources & evidence

ORD record
ord-fe2cb20ba56644f19908179963f5f998
Source dataset
uspto-grants-1976_11
Patent number
US03995056

Reaction notes

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