反应详情

To a flask equipped with a stirrer, condenser and gas inlet tube maintained under a nitrogen atmosphere there is added at room temperature 16.3 g (0.05 mole) of 2-(β-[2-dimethylaminoethyl]-β-hydroxyphenethyl)-N-methylbenzamide and 170 ml of o-dichloro benzene. Stirring is initiated and the mixture is heated at reflux for 18 hours. The excess o-dichlorobenzene is then removed by distillation in vacuo and the resulting oil is crystallized from ether to give 3-[2-dimethylaminoethyl]-3,4-dihydro-3-phenylisocoumarin; m.p. 95.0°-95.5° C.

1. customTo a flask equipped with a stirrer, condenser and gas inlet tube
2. temperaturemaintained under a nitrogen atmosphere
3. temperaturethe mixture is heated
4. temperatureat reflux for 18 hours
5. customThe excess o-dichlorobenzene is then removed by distillation in vacuo
6. customthe resulting oil is crystallized from ether