Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | (S)-Methyl 2-amino-3-(tert-butoxy)propanoate | HCID 7018830 | — |
| Reactant | Z-Thr(tBu)-OSU | HCID 13503275 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Z-Thr(But)-Ser(But)-OMe | HCID 131710554 | — |
Reaction Steps
16.25 g of Z-Thr(But)-OSu and 8.47 g of H-Ser(But)-OMe. HCl are added to 200 ml of ethyl acetate, 5.6 ml of triethylamine are added at 0°C and the solution is stirred for 15 hours at 20°C and washed with 1 N citric acid, 1 N sodium bicarbonate and water. After drying over sodium sulphate, the solution is evaporated, whereupon the product, which is pure according to thin layer chromatography, is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03994871 |
|---|
| Source dataset | uspto-grants-1976_11 |
|---|
| ORD ID | ord-be6a612873934733895b42cd6419d82f |
|---|
| Source note | uspto-grants-1976_11 |
|---|
