Hydrochloric Acid → HCID 131710557, compound

Participants

Reaction Conditions

Reaction Steps

3.6 g of Trt-Cys(Trt)-Cys(Acm)-Thr(But)-Ser(But)-Ile-Cys(Trt)-Ser(But)-Leu-OMe are dissolved in 50 ml of dioxane and 17 ml of water and 4 ml of 1 N sodium hydroxide solution are added. After 1 hour at 20°C the mixture is cooled to 0°C and 4 ml of 1 N hydrochloric acid are added dropwise. The dioxane is then largely evaporated off at 20°C under reduced pressure, 20 ml of water are added and the precipitate is filtered off and dried over potassium hydroxide.

Provenance & Evidence