Ethyl bromoacetate → Ethyl 2-(4-fluorophenoxy)acetate

Participants

Reaction Steps

A mixture of 13.8 g (0.1 mole) potassium carbonate, 11.3 g (0.01 mole) 4-fluorophenol and 13.0 ml (19.6 g [0.11 mole]) ethyl bromoacetate in 100 ml methyl ethyl ketone were stirred overnight at room temperature and then heated at reflux for 5 hours. After the reaction mixture cooled to room temperature, it was filtered. The filtrate was concentrated to remove solvent. The concentrate was used as a whole without further isolation in Example 2.

Provenance & Evidence