Trifluoromethanesulfonic acid → HCID 54411206, compound

Participants

Reaction Steps

One gram of the 3-(1,2,3,3,3-pentafluoropropen-1-yl)-5-trimethylsilyl-2-thiophenesulfonamide prepared in (3) was treated with 4 ml of trifluoromethanesulfonic acid under stirring at room temperature for 2 hours. After completion of the reaction, the resulting product was poured into water and extracted with methylene chloride. The extracted layer was washed with water and dried. After distilling off methylene chloride, the residue was purified by column chromatography on silica gel (eluent: methylene chloride) to provide 0.67 g of 3-(1,2,3,3,3-pentafluoropropen-1-yl)-2-thiophenesulfonamide having a melting point of 108° to 111° C.

Provenance & Evidence