HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 5-bromo-1-phenyl-1H-pyrazole-4-carboxylate | HCID 13802165 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid | HCID 13821931 | 64.2% |
Reaction Steps
A mixture of 15.5 g of 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester and 14 g of potassium hydroxide in 300 ml of 3A ethanol was refluxed for 3 hours. The solution was poured into ice water and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration and recrystallized from ethanol/water to afford 9.0 g of 5-bromo-1-phenyl-1H-pyrazole-4-carboxylic acid. Yield 64%. mp=218°-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04620865 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-083461fef2d6464ea91059f8e43a1bf7 |
| Source note | uspto-grants-1986_11 |