HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl 5-amino-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | m-Chlorophenylhydrazine hydrochloride | HCID 75331 | — |
| Reactant | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5-amino-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylate | HCID 757292 | 67% |
Reaction Steps
A solution of 53.7 g of (3-chlorophenyl)hydrazine hydrochloride, 50.8 g of ethyl(ethoxymethylene)cyanoacetate and 41.4 g of potassium carbonate in 500 ml of ethanol was refluxed for 20 hours. The solution was poured into ice water. The precipitated solid was collected by filtration, dried and recrystallized from ethanol/water to provide 53.0 g of 5-amino-1-(3-chlorophenyl)-1H-pyrazole-4-carboxylic acid, ethyl ester. Yield 67%. mp=115°-117° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04620865 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-92765eba177d4875b6ce732748c3c743 |
| Source note | uspto-grants-1986_11 |