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Hydrochloric Acid → 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl 5-Chloro-1-methyl-1H-pyrazole-4-carboxylate | HCID 2758821 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid | HCID 2735774 | — |
反応手順
5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester (13 grams, 0.07 mole) and potassium hydroxide (7.8 grams, 0.14 mole) were combined in 75 ml. of ethanol and refluxed for six hours. The solution was cooled, poured over water, acidified with concentrated hydrochloric acid, and the precipitated solid collected, dried, and recrystallized from water. The resulting 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid was obtained in the amount of 5.4 grams and melted at 195°-197° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04620865 |
| 出典データセット | uspto-grants-1986_11 |
| ORD ID | ord-4250428618d14b3b878acef53985b60c |
| 出典メモ | uspto-grants-1986_11 |