HCID 70455822, compound → HCID 20228775, compound

HRID 1731292Notes

Reaction equation

HRID 1731292 reaction equation
[NH:1]1[CH:5]=[C:4]([NH:6]/[C:7](=[CH:13]\[C:14]([O:16]CC)=O)/[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:3]=[N:2]1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[O:16]=[C:14]1[CH:13]=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[NH:6][C:4]2[CH:5]=[N:1][NH:2][C:3]1=2

Participants

3

Reactant 1

HCID 70455822HCID 70455822, compound

Product 1

HCID 20228775HCID 20228775, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Procedure

Diethyl 2-(pyrazol-4-ylamino)fumarate (7.74 g, 30 mmol) was added to boiling Dowtherm A (250 ml). The solution was heated under reflux for 10 min, and then allowed to cool to room temperature. 60°-80° petrol (250 ml) added and the solid was collected and washed well with petrol, to give the title compound as pale yellow needles (5.77 g, 99%), m.p. 287°-292° C.

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 10 min
  3. customthe solid was collected
  4. washwashed well with petrol

Sources & evidence

ORD record
ord-d68e61a781024d0bbd57fd288c7b15d3
Source dataset
uspto-grants-1986_11
Patent number
US04621089

Reaction notes

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