反应详情

Ethyl 7-chloro-1H-pyrazolo[4,3-b]-pyridine-6-carboxylate (370 mg, 1.6 mmol) was dissolved in aniline (3 ml) and stirred overnight. The resulting mixture was triturated with 60°-80° petrol, and the precipitated solid was collected and dissolved in aqueous ethanol. The solution was adjusted to pH 8 with saturated sodium hydrogen carbonate solution, and the precipitated solid was collected to give the title compound (310 mg, 67%) m.p. 164°-165° C.

1. customThe resulting mixture was triturated with 60°-80° petrol
2. customthe precipitated solid was collected
3. dissolutiondissolved in aqueous ethanol
4. customthe precipitated solid was collected