Ammonia → HCID 70382170, compound

Participants

Reaction Steps

A solution of cis-octahydro-1-oxo-2H-isoindole-2acetic acid ethyl ester (17.79 g, 0.079 mole) in methanol (100 ml) is saturated with anhydrous ammonia and the solution is stirred 18 hours at room temperature. The solution is concentrated at reduced pressure to yield a gummy solid. Recrystallization from acetonitrile yields pure cis-octahydro-1-oxo-2H-isoindole-2-acetic acid amide, with mp 142°-144° C.

Provenance & Evidence