Ammonia → HCID 70382278, compound

HRID 1731307Notes

Reaction equation

HRID 1731307 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH2:10][C@@H:9]2[CH2:11][CH2:12][CH2:13][C@@H:8]2[C:7]1=[O:14])C.[NH3:16]>CO>[O:14]=[C:7]1[C@H:8]2[CH2:13][CH2:12][CH2:11][C@H:9]2[CH2:10][N:6]1[CH2:5][C:4]([NH2:16])=[O:3]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 70382709HCID 70382709, compound

Product 1

HCID 70382278HCID 70382278, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cis-hexahydro-1-oxo-cyclopenta[c]pyrrole-2(1H)-acetic acid ethyl ester (25 g, 0.0154 mole) in methanol is saturated with anhydrous ammonia and the mixture is stirred at room temperature 24 hours. The solution is concentrated at reduced pressure to yield a solid with mp 138°-141° C. Recrystallization (acetonitrile) yields pure cis-hexahydro-1-oxo-cyclopenta[c]pyrrole-2(1H)-acetamide with mp 142.5°-143.5° C.

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid with mp 138°-141° C
  3. customRecrystallization (acetonitrile)

Sources & evidence

ORD record
ord-fa5fad14fdcb46c79717cd06b54d45e9
Source dataset
uspto-grants-1986_11
Patent number
US04621097

Reaction notes

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