4-Chlorophenol → HCID 13295541, compound

Participants

Reaction Steps

12.85 g (0.1 mol) of 4-chlorophenol in 50 ml of acetone are added dropwise to a mixture of 14.1 g (0.1 mol) of 2,2-di(chloromethyl)-oxirane and 13.8 g (0.1 mol) of potassium carbonate in 200 ml of acetone. The mixture is heated under reflux for 18 hours, left to cool and filtered. The filtrate is concentrated in vacuo, the residue is dissolved in chloroform and the solution is washed with water, dried over sodium sulphate and concentrated. Purification of the residue by distillation gives 7.6 g (32.5% of theory) of 2-chloromethyl-2-(4-chlorophenoxymethyl)-oxirane of boiling point 150° C./0.5 mbar.

Provenance & Evidence