1H-1,2,4-Triazole → HCID 13295582, compound

Participants

Reaction Steps

28.2 g (0.2 mol) of 2,2-di(chloromethyl)-oxirane are added dropwise to a mixture of 82.5 g (1.2 mol) of 1,2,4-triazole and 82.5 g (0.6 mol) of potassium carbonate in 400 ml of acetone, whilst stirring. The reaction mixture is stirred under reflux for 50 hours and filtered and the filtrate is concentrated in vacuo. The oily residue is chromatographed (silica gel 60, Merck, chloroform/methanol=20/1). 5.9 g (10.7% of theory) of 1,3-di-(1,2,4-triazol-1-yl)-2-hydroxy-2-(1,2,4-triazol-4-yl-methyl)-propane of melting point 220° C. are obtained.

Provenance & Evidence