反应详情

To a suspension of aluminum chloride (91.8 g) in carbon disulfide (200 ml) was added 2-bromopropionyl bromide (50 g) and 2-benzothiazolinone (20 g) and the resulting solution was refluxed for 6 hours with stirring. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was washed with brine and dried over magnesium sulfate. The solvent was removed in vacuo to give a residue, which was washed with diisopropyl ether and recrystallized from a mixture of ethyl acetate and diethyl ether to give 5-(2-bromopropionyl)-2-benzothiazolinone (32.3 g).

1. temperaturethe resulting solution was refluxed for 6 hours
2. extractionextracted with ethyl acetate
3. washThe extract was washed with brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed in vacuo
6. customto give a residue, which
7. washwas washed with diisopropyl ether
8. customrecrystallized from a mixture of ethyl acetate and diethyl ether