Nitric Acid → HCID 13922465, compound

Participants

Reaction Steps

To 35 ml of nitric acid (fuming, d=1.50) was added portionwise 3,7-dimethyl-2-(4-acetamidophenyl)imidazo-[1,2-a]pyridine (5.6 g) at 3°-10° C. for a period of 10 minutes and the mixture was stirred for 30 minutes at the same temperature. The reaction mixture was poured into ice-water (500 ml) and the precipitates collected by filtration, were washed with water (100 ml×4) and dried over phosphorus pentoxide under reduced pressure to give 3,7-dimethyl-2-(4-acetamido-3-nitrophenyl)-imidazo[1,2-a]pyridine (3.3 g). mp. 204°-208° C. (dec.).

Provenance & Evidence