2-Aminopyridine → HCID 20228712, compound

HRID 1731334Notes

Reaction equation

Br[CH:2]([CH3:17])[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[S:13][CH2:12][C:11](=[O:14])[N:10]([CH3:15])[C:9]=2[CH:16]=1)=O.[NH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1>>[CH3:17][C:2]1[N:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]2=[N:18][C:3]=1[C:5]1[CH:6]=[CH:7][C:8]2[S:13][CH2:12][C:11](=[O:14])[N:10]([CH3:15])[C:9]=2[CH:16]=1

Participants

Reactant 2

HCID 104392-Aminopyridine

HCID 20228672HCID 20228672, compound

Product 1

HCID 20228712HCID 20228712, compoundYield 67.9%

Procedure

6-(3-Methylimidazo[1,2-a]pyridin-2-yl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazine (2.1 g) was prepared in the substantially same manner as that of Example 4 from 6-(2-bromopropionyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazine (3.14 g) and 2-aminopyridine (2.85 g).

Sources & evidence

ORD record: ord-0ec9f3d0919844c2a41ab934c2aed6df
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04621084

Reaction notes

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