反应详情

A solution of 5-(2-bromopropionyl)-2-benzothiazolinone (2.9 g) and 2-aminopyrimidine (2.9 g) in acetonitrile (100 ml) was refluxed for 15 hours with stirring. The reaction mixture was cooled to ambient temperature to give a precipitate, which was collected by filtration. The precipitate was added to a mixture of water and ethyl acetate and the resulting mixture was adjusted to pH 8.0 with 20% aqueous potassium carbonate solution. The precipitate was collected by filtration, washed successively with water and ethanol and dried over phosphorus pentoxide to give 5-(3-methylimidazo-[1,2-a]pyrimidin-2-yl)-2-benzothiazolinone (1.45 g).

1. customto give a precipitate, which
2. filtrationwas collected by filtration
3. additionThe precipitate was added to a mixture of water and ethyl acetate
4. filtrationThe precipitate was collected by filtration
5. washwashed successively with water and ethanol
6. dry with materialdried over phosphorus pentoxide