HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-methylpyrimidine → 6-(3,7-Dimethylimidazo[1,2-a]pyrimidin-2-yl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-methylpyrimidine | HCID 7939 | — |
| Reactant | 6-(2-Bromopropanoyl)-2-methyl-2H-1,4-benzoxazin-3(4H)-one | HCID 20228676 | — |
| Product | 6-(3,7-Dimethylimidazo[1,2-a]pyrimidin-2-yl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine | HCID 20228674 | 41.9% |
Reaction Steps
6-(3,7-Dimethylimidazo[1,2-a]pyrimidin-2-yl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (1.3 g) was prepared in substantially the same manner as that of Example 16 from 6-(2-bromopropionyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (3.0 g) and 2-amino-4-methyl-pyrimidine (3.3 g). mp. 298° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04621084 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-41ae4f8c7bbc4de99bc8f20699dc2490 |
| Source note | uspto-grants-1986_11 |