2-Aminopyrimidine → HCID 20228733, compound

HRID 1731348Notes

Reaction equation

HRID 1731348 reaction equation
Br[CH:2]([CH3:17])[C:3]([C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH3:14])[C:11](=[O:15])[NH:10][C:9]=2[CH:16]=1)=O.[NH2:18][C:19]1[N:24]=[CH:23][CH:22]=[CH:21][N:20]=1>>[CH3:17][C:2]1[N:20]2[CH:21]=[CH:22][CH:23]=[N:24][C:19]2=[N:18][C:3]=1[C:5]1[CH:6]=[CH:7][C:8]2[O:13][CH:12]([CH3:14])[C:11](=[O:15])[NH:10][C:9]=2[CH:16]=1

Participants

3

Reactant 2

HCID 79782-AminopyrimidineHCID 202286766-(2-Bromopropanoyl)-2-methyl-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 20228733HCID 20228733, compoundYield 37.1%

Procedure

6-(3-Methyl-imidazo[1,2-a]pyrimidin-2-yl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (1.1 g) was prepared in substantially the same manner as that of Example 16 from 6-(2-bromopropionyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (3.0 g) and 2-aminopyrimidine (2.9 g). mp. 288°-290° C. (dec.).

Sources & evidence

ORD record
ord-800d465942e1458280ae20953bfa3992
Source dataset
uspto-grants-1986_11
Patent number
US04621084

Reaction notes

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