Dimethylamine → HCID 20228668, compound

HRID 1731368Notes

Reaction equation

[N:1]1[C:2]([C:10]2[CH:11]=[CH:12][C:13]3[S:17][C:16](=[O:18])[N:15]([CH3:19])[C:14]=3[CH:20]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.[CH2:21]=O.[CH3:23][NH:24][CH3:25]>>[CH3:23][N:24]([CH2:21][C:3]1[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]2=[N:1][C:2]=1[C:10]1[CH:11]=[CH:12][C:13]2[S:17][C:16](=[O:18])[N:15]([CH3:19])[C:14]=2[CH:20]=1)[CH3:25]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 712Formaldehyde

HCID 20228667HCID 20228667, compound

Product 1

HCID 20228668HCID 20228668, compoundYield 59.6%

Procedure

5-(3-Dimethylaminomethylimidazo[1,2-a]pyridin-2-yl)-3-methyl-2-benzothiazolinone (6.35 g) was prepared in substantially the same manner as that of Example 50 from 5-(imidazo[1,2-a]pyridin-2-yl)-3-methyl-2benzothiazolinone (8.86 g), 30% aqueous formaldehyde (2.57 g) and 50% aqueous dimethylamine (2.97 g).

Sources & evidence

ORD record: ord-ac77ffc40fdb42cbb210c05c1e690516
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04621084

Reaction notes

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