Hydrochloric Acid → Ibuprofen, (+-)-

Participants

Reaction Conditions

Reaction Steps

Methyl 3-methyl-3-(4-isobutylphenyl)pyruvate (1.19 g, 4.8 mmol) was dissolved in a 1N sodium hydroxide aqueous solution (15 ml), and a 35% hydrogen peroxide aqueous solution (5.0 ml) was dropwise added under cooling (0° C.) and stirring. The temperature of the mixture was returned to room temperature, and the mixture was stirred overnight. Then, mixture was acidified with hydrochloric acid and extracted with ether, whereby 2-(4-isobutylphenyl)propionic acid (0.78 g, yield: 79%) was obtained.

Provenance & Evidence