Toluene → HCID 178444316, compound

HRID 1731452Notes

Reaction equation

HRID 1731452 reaction equation
C[Mg]I.[CH2:4]([C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]2[CH:22]=[CH:21][C:18](C#N)=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)[CH2:5][CH2:6][CH:7]=[CH2:8].C1(C)C=CC=CC=1.C([O:32][CH2:33][CH3:34])C>>[CH2:4]([C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15]2[CH:16]=[CH:17][C:18]([C:33](=[O:32])[CH3:34])=[CH:21][CH:22]=2)[CH2:13][CH2:14]1)[CH2:5][CH2:6][CH:7]=[CH2:8]

Participants

5

Reactant 4

HCID 1140TolueneHCID 3283Diethyl EtherHCID 178418373HCID 178418373, compoundHCID 178444325HCID 178444325, compound

Product 1

HCID 178444316HCID 178444316, compoundYield 134.9%

Procedure

A solution of methylmagnesium iodide in diethyl ether (prepared from 195 mg of magnesium shavings and 0.495 ml of methyl iodide in 15 ml of diethyl ether) was treated dropwise at room temperature with a solution of 1.0 g of p-[trans-4-(4-pentenyl)cyclohexyl]benzonitrile. The mixture was heated to reflux for 15 minutes. Subsequently, 15 ml of toluene were added to the reaction mixture, the diethyl ether was distilled off and the mixture was heated to reflux for a further 1.5 hours. Thereafter, the reaction mixture was treated cautiously at 0° C. with saturated ammonium chloride solution and partitioned three times in diethyl ether/washed twice with water, dried over magnesium sulphate, filtered and evaporated. Chromatographic separation of the yellow crystalline residue (1.1 g) on silica gel with ethyl acetate/petroleum ether (vol. 5:95) gave 0.96 g (90%) of p-[trans-4-(4-pentenyl)cyclohexyl]acetophenone as light yellow crystals; m.p. 47.6° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 15 minutes
  3. distillationthe diethyl ether was distilled off
  4. temperaturethe mixture was heated
  5. temperatureto reflux for a further 1.5 hours
  6. additionThereafter, the reaction mixture was treated cautiously at 0° C. with saturated ammonium chloride solution
  7. custompartitioned three times in diethyl ether/
  8. washwashed twice with water
  9. dry with materialdried over magnesium sulphate
  10. filtrationfiltered
  11. customevaporated
  12. customChromatographic separation of the yellow crystalline residue (1.1 g) on silica gel with ethyl acetate/petroleum ether (vol. 5:95)

Sources & evidence

ORD record
ord-139df02432a646dd900f6260174c5d17
Source dataset
uspto-grants-1986_11
Patent number
US04621901

Reaction notes

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