HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl chloroformate → Methyl 2-bromo-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl chloroformate | HCID 6586 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Bromo-4-fluorophenol | HCID 605472 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-bromo-4-fluorobenzoate | HCID 7210837 | — |
Reaction Steps
To a solution of 2-bromo-4-fluorophenol (28 g) in a solution of sodium hydroxide (7 g) in water (100 ml), methyl chloroformate was dropwise added thereto at a temperature below 10° C. The produced crystals were collected by filtration and washed with water to give methyl 2-bromo-4-fluorophenylformate (41 g). M.P., 80.7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622063 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-ed99995e4e5e46b294a21ee4f8e07f24 |
| Source note | uspto-grants-1986_11 |