HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 70446069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 86740921 | HCID 86740921 | — |
| Reactant | HCID 86740923 | HCID 86740923 | — |
| Reactant | CID 53628100 | HCID 178418400 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Product | HCID 70446069 | HCID 70446069 | — |
Reaction Steps
The 2,2,5,5-tetramethyl cyclopentylmethyl triphenylphosphonium bromide is suspended in tetrahydrofuran at 0° C. under argon. Sec-Butyllithium in cyclohexane is added followed by a solution of 2-benzyloxycarbonyl-2-CBZ-aminoacetaldehyde in tetrahydrofuran. After one hour, water is added to the reaction mixture. The organic layer is separated, washed with water and dried over MgSO4 and evaporated to yield the alkene, benzyl 2-CBZ-amino-4-(2,2,5,5-tetramethylcyclopentyl)-3-butenoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04622232 |
| Source dataset | uspto-grants-1986_11 |
| ORD ID | ord-11cc6a0f7d324422a11a8a79bc87c34d |
| Source note | uspto-grants-1986_11 |