HCID 12852270, compound → HCID 12884300, compound

Participants

Reaction Conditions

Reaction Steps

To concentrated sulphuric acid (350 ml), N-[2-nitro-5(2-chloro-4-{trifluoromethyl}phenoxy)phenyl]acetamide (75.5 g; 0.2 mole) is added in small portions in the course of twenty minutes. The temperature rises to 30° C. The reaction mixture is then heated to 50° C. for 2 hours and, after being cooled, is then poured onto ice/water (1 kg). The solid thus obtained is purified by chromatography to give 1-amino-2-nitro-5-[2-chloro-4-(trifluoromethyl)phenoxy]benzene (44 g), m.p. 100° C. Yield 69%.

Provenance & Evidence