Benzoyl chloride → HCID 20227707, compound

HRID 1731520Notes

Reaction equation

Cl.[OH:2][CH2:3][CH:4]1[CH:7]2[C:8]3[C:13]([CH2:14][CH2:15][N:6]2[CH2:5]1)=[CH:12][C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=3.[C:20]([Cl:28])(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[ClH:28].[C:20]([O:2][CH2:3][CH:4]1[CH:7]2[C:8]3[C:13]([CH2:14][CH2:15][N:6]2[CH2:5]1)=[CH:12][C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=3)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 20227708HCID 20227708, compound

Product 1

HCID 20227707HCID 20227707, compound

Procedure

0.01 mole (1,85 g) of 1-(hydroxymethyl)-7,8-dimethoxy-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinoline hydrochloride is acylated with benzoyl chloride following the conventional Schotten-Baumann acylation method.

Sources & evidence

ORD record: ord-02c2a7d6d2b74195aee1a825d0c65aa5
Source dataset: uspto-grants-1986_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04622327

Reaction notes

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